spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 4


Fig. 4. Profilin1 is required for Wnt3a and Dishevelled-mediated stress fiber induction. (A) Transfection of Profilin1 siRNA but not GFP siRNA into NIH3T3 cells inhibits stress fiber induction (green) by 3 hours Wnt3a CM or Wnt3a protein stimulation. Note the Profilin1 siRNA does not inhibit stress fiber induction induced by serum stimulation. Nuclear translocation of endogenous ß-catenin (red) induced by Wnt3a CM or purified Wnt3a protein stimulation is not affected by Profilin1 siRNA. (B) Transfection of Profilin1 siRNA but not GFP siRNA into NIH3T3 cells inhibits stress fiber induction (green) induced by {Delta}DIX-Dishevelled expression (red), magnifications of the boxed areas (white) are shown at the side of each respective panel. (C) Quantification of the results of A and B. Number of cells evaluated is shown at the top of each bar.





Right arrow Return to article