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Figure 8


Fig. 8. Profilin1 is not required for tissue separation or convergent extension. (A) Overexpression (2 ng RNA) or depletion of Profilin1 (50 ng XProfilin1 MO) does not inhibit convergent extension in animal explants treated with activin or (C) in Keller explants whereas dominant negative Dishevelled (Xdd1, 2 ng) inhibits these movements. (E) Overexpression (2 ng RNA) or depletion of Profilin1 (50 ng XProfilin1 MO) does not inhibit tissue separation by 1 hr whereas injection of Xfz7 (1 ng) does. Quantitation of the convergent extension assays in (B) animal explants, (D) Keller explants and (F) separation assays. For animal explant assays, a length/width ratio of 2 or higher was scored as elongated. For Keller explants, a length/width ratio below 2 was scored as a short elongation and a length/width ratio of 2 or higher was scored as a long elongation.





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