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Fig. 5. Expression of cell-adhesion molecules in pseudoglandular structures of
the 17.5-day knockout liver. Intrahepatic biliary epithelial cells
(arrows) are negatively or weakly immunostained for 
3 and ß4
integrin subunits in the wild-type liver (A,B) although
extrahepatic bile duct cells are moderately immunostained for ß4 integrin
subunits (B). E-cadherin expression is strong in biliary epithelial cells, but
they have weak N-cadherin expression in the wild-type liver (arrows)
(C,D). In the knockout liver, cells of periportal
pseudoglandular structures moderately express both integrin subunits
(arrowheads) (E,F). In addition, almost all cells of
pseudoglandular structures strongly or moderately express E-cadherin and
N-cadherin (G,H) but those around the portal vein are negative
for N-cadherin (arrowhead, H). PV, portal vein. Scale bars: 50 µm.
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