spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 9


Fig. 9. Liver fragments of knockout fetuses develop cystic structures in the testes of Scid mice. Liver fragments of 12.5-day wild-type and knockout fetuses were transplanted and maintained for 2 months in the testes of Scid mice, and histologically and histochemically analyzed for expression of cell type-specific markers. The wild-type liver developed normal hepatic tissues, in which the portal vein and hepatic vein differentiated (A,B). Hepatocytes store PAS-positive glycogen. Periportal biliary cells (arrows) are immunostained for bile duct-specific cytokeratin (C), type IV collagen (E) and nidogen (F) but are negative for DBA-binding sites (D). By contrast, the knockout liver developed abundant cystic structures strongly expressing bile duct markers in the testis (G-L). Normal hepatic tissues are also observed with cystic structures in a few knockout transplants (G; Hematoxylin and Eosin staining). HV, hepatic vein; PV, portal vein. Scale bars: 50 µm.





Right arrow Return to article