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Figure 7


Fig. 7. Model for Rho1 activity during spiracle cell invagination and tube formation. Rho1 is exclusively active at the apical domain of the invaginating cells that form the spiracular chamber, by the action of RhoGEF2 and RhoGEF64C. At the apical side Rho1-GTP promotes Myosin II and F-Actin assembly/activity, being essential for correct cell invagination and lumen maintenance. Rho1 function is excluded from the basolateral domain both by the absence of RhoGEF activity and by the presence of the RhoGAP Cv-c. Inactivation of Rho1 at the basolateral domain is also required to maintain the steady state levels of apical Rho1-GTP.





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