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Fig. 7. Vnd represses glial fate in the early trito- and deutocerebrum.
(A-H) Head flat preparations double stained with antibodies against the glial
marker Repo and En in wild-type (wt; A,B), msh mutant
(msh-; C,D), vnd mutant (vnd-; E,F) and
sca-vnd embryos (G,H) at early stage 12, all in a ventral view.
(B,D,F,H) Close-ups of regions framed in (A,C,E,G), respectively.
(A,B) In the TC and DC, first glial cells develop in the dorsal
pNE. In contrast, in the PC, some of the glial cells appear to develop from
ventral NBs. Broken red lines indicate segmental boundaries.
(C,D) In msh-, glial cells in the TC and DC are almost
absent (one cryptic glial cell is detected at dorsalmost position in the DC;
white arrowhead in D). Similarly, the number of glia cells in the MD, MX and
LA is diminished (C). Glial cells are not affected in the PC.
(E,F) In vnd-, the number of glial cells is
significantly increased in the TC and DC. Most of the ectopic glial cells
develop in the ventral TC and DC (F), as is indicated by their position
relative to the en antennal stripe (as) and en head
spot (hs). (G,H) In sca-vnd, glial cells are
absent in the TC and DC, strongly resembling the phenotype in msh-.
However, glia cell number is also reduced in the PC.
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