QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online October 12, 2006

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

An enhanced view of myocardin transcription

Myocardin, an early cardiac and smooth muscle cell lineage marker, is a transcriptional co-activator of serum response factor (Srf), which regulates the expression of many myogenic genes. But what regulates myocardin expression? On p. 4245, Eric Olson's team reports that a combination of Mef2, Tead and Foxo transcription factors regulates myocardin expression during cardiovascular development. By examining the expression of a lacZ reporter gene linked to various non-coding regions of the gene in transgenic mice, the researchers identified a 10 kb fragment that recapitulates the expression pattern of myocardin during cardiogenesis. They then homed in on a 350 bp enhancer region within this fragment, the activity of which requires the combined action of Mef2 and Foxo in cardiomyocytes, plus Tead in smooth muscle cells. Other results indicate that, unlike most myogenic genes, myocardin expression does not depend on Srf. Instead, myocardin activates its own enhancer via Mef2. This suggests that a unique positive-feedback loop regulates smooth- and cardiac-muscle-specific transcription during cardiovascular development.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development

Esther E. Creemers, Lillian B. Sutherland, John McAnally, James A. Richardson, and Eric N. Olson
Development 2006 133: 4245-4256. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?