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Figure 1


Fig. 1. A model for the structure of the RNA polymerase II transcription pre-initiation complex. The structure of RNA PolII (white), TFIIB (yellow), TBP (green) and promoter DNA, where the positions of the protein and DNA have been deduced from site-specific hydroxyl radical cleavage and photocrosslinking. The blue patches on the surface of RNA PolII are hydroxyl radical cleavage sites derived from Fe-EDTA probes inserted in the DNA backbone. The highlighted base pair (purple and red) is the presumed initiation site for DNA-strand separation. Modified, with permission, from Miller and Hahn (Miller and Hahn, 2006).





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