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Fig. 6. Hypothetical pathways that might link Wnt signalling to changes in the cytoskeletal organisation of the growth cone. Components typical of the non-canonical PCP pathway are represented in dark green, the classical or divergent canonical pathway in light blue, and the Ca²⁺ pathway in purple. General modulators of `classical' guidance cues are represented in pink. This hypothetical link suggests that components of the PCP pathway could mainly regulate actin dynamics (green), whereas, independently of transcriptional activity, the canonical pathway could regulate microtubule dynamics through Gsk3ß. Apc may function to link microtubule and microfilament dynamics. Apc, adenomatous polyposis coli; ASEF, rac-specific guanine nucleotide exchange factor; Axin, axis inhibition protein; CamKII, calcium/calmodulin-dependent protein kinase II; Cdc42, cell division cycle 42; cGMP, cyclic guanosine monophosphate; CRMP, collapsin response mediator protein; Daam1, dishevelled associated activator of morphogenesis 1; DAG, diacylglycerol; Dvl, dishevelled; Eph, ephrin receptor; Fried, frizzled-8 associated multidomain protein; Fz, Frizzled receptor; G, G-protein; Gsk3ß, glycogen synthetase kinase 3; IP3, inositol 1,4,5-trisphosphate receptor; JNK, jun kinase; LIMK, LIM domain kinase; Map1B, microtubule-associated protein 1B; PDE, phosphodiesterase; PKC, protein kinase C; PLC, phosphatidylinositol-specific phospholipase C; Rac, GTPase activator; Rho, ras homolog; Rok, Rho kinase; Ryk, receptor-like tyrosine kinase; Tau, neurofibrillary tangle protein.

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