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Fig. 5. Deletion of Jag1 blocks the ability of ß-catenin to induce new hair follicles. (A-I) Back skin sections of 4OHT-treated Jag1^flox/flox (A,D,E), K14N ß-cateninER (B,F,G) and triple transgenic mice (C,H,I). Sections were stained with H&E (A-C) or with antibodies to jagged 1 (D,F,H) and ß-catenin (E,G,I) with DAPI counterstain (blue). E,G,I show nuclear pool of ß-catenin in IFE. Scale bars: 50 µm in E,G,I; 100 µm in A-C,D,F,H. (J-U) Whole mounts of tail epidermis from 4OHT-treated Jag1^flox/flox, K14N ß-cateninER and triple transgenic mice labelled with antibodies to K14 (J,N,R), CDP (L,P,T), ß1 integrin (red) and Ki67 (green) (M,Q,U), or stained with Nile Red (green) and DAPI (K,O,S). Dashed lines outline hair follicles and sebaceous glands. Scale bar: 100 µm.

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