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Fig. 6. Notch activation enhances ß-catenin-induced ectopic hair follicle formation and maturation. (A-L) Back skin of wild-type (A,D,G), K14 ${Delta}$ N ß-cateninER (ßcatER) (B,E,H,K) and K14 ${Delta}$ N ß-cateninERxK14N^ICDOPER double (ßcatER/N^ICDOPER) (C,F,I,L) transgenic mice treated with 4OHT for 8 days. Sections were stained with H&E (A-C) or with antibodies to CDP (D-F), Ki67 (G-I) or trichohyalin (J-L). Arrows mark new follicles arising from preexisting follicles. (J) Quantitation of number of CDP positive areas (±s.e.m.) per existing follicle in K14 ${Delta}$ N ß-cateninER single or K14 ${Delta}$ N ß-cateninERxK14N^ICDOPER double transgenics treated with 4OHT for the number of days shown. (M-Q) Epidermis of TNR mice crossed with wild-type (WT;M,O) or K14N^ICDOPER (N,P) or K14 ${Delta}$ N ß-cateninER (Q) mice stained with antibodies to GFP (brown). Scale bars: 100 µm.

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