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Fig. 6. Downregulation of Ptf1a expression in the
Foxn4-/- retina. (A) Real-time qRT-PCR analysis
of Ptf1a, Foxn4 and Gapdh mRNA levels in E14.5
Foxn4+/- and Foxn4-/- retinas. Each
histogram represents the mean±s.d. for four retinas. (B-E)
Retinal sections of the indicated stages from wild-type and mutant mice were
hybridized with a Ptf1a riboprobe. The absence of Ptf1a
signals from Foxn4-/- retinas (C,E). Scale bar: 50 µm
in B,C; 25 µm in D,E. Abbreviations: onbl, outer neuroblastic layer; inbl,
inner neuroblastic layer.
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