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Fig. 6. Kidney defects in the Cv2 mutant. (A-D) External
appearances (A,B) and longitudinal sections (C,D; along the longest axis) of
the kidneys at P0. Scale bars: 500 µm. Reduced kidney size was observed in
the Cv2-/- mutant (B,D). (E,F) HE staining
showed no obvious morphological defects of the renal corpuscle in the
Cv2-/- mutant kidney at P0 (F). (G,H) The
kidney was smaller in the Cv2-/- mutant (H) at E14.5.
(I,J) Whole-mount in situ hybridization of Pax2
expression in the control (I) and mutant (J) kidneys. The
Pax2-positive condensed mesenchymes were formed in the mutant, but
the number was reduced (K; *P<0.05,
t-test). (L,M) WT1-positive condensed mesenchymes and
glomerular podocytes (green) and E-cadherin-positive collecting ducts (red)
are shown in whole-mount immunostaining. The general architecture of the
kidney was largely unaffected in the Cv2-/- mutant
(M).
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