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Figure 7


Fig. 7. Kidney defects are enhanced in the Cv2;Kcp compound mutant. (A) Numbers of the glomeruli in the maximal longitudinal section of the kidney. There was a significant difference between the control and Cv2-/- mutant kidneys. In addition, a significant difference was found between the Cv2-/- mutant with both Kcp alleles and that without one or two Kcp alleles (***P<0.001; Tukey test). Error bars show s.d.; n.s., no significant difference. (B-G) External appearances (B-D) and longitudinal sections (E-G; along the longest axis) of the kidneys at P0. Scale bars: 500 µm. (B,E) There was no decrease in size in the Kcp-/- kidney, even on the Cv2+/- background (not shown). (C,D,F,G) The small-kidney phenotype of the Cv2-/- mutant was enhanced on the Kcp+/- and Kcp-/- backgrounds.





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