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Fig. 6. Contribution of extracardiac cells from the AHF is unaffected in
Hand1-overexpressing embryos. RNA in situ hybridisation analysis
of Isl1 and Mef2c in control embryos
(A,C,E,G,I,K) and moderate phenotype
Hand1-overexpressing embryos
(B,D,F,H,J,L) at E9.5. Right lateral
views of whole-mount embryos (A,B,G,H). Sagittal sections of the control
(C,E,I,K) and Hand1-overexpressing hearts (D,F,J,L). There are no
apparent differences in expression of the AHF marker Isl-1 between
control and overexpressing embryos (compare A,C,E with B,D,F) or in expression
of markers of AHF derivatives, as indicated by Mef2c (compare G,I,K
with H,J,L). aa, aortic arch(es); at, atrium; ba, branchial arch; co, control;
oe, overexpression; oft, outflow tract; rv, right ventricle. Scale bars: 200
µm in A for A,B,G,H; 50 µm in E for C-F,I-L.
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