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Fig. 8. Primary heart field markers are downregulated in
Hand1-overexpressing embryos. RNA in situ hybridisation analysis
of Nkx2.5 and Gata4 in control embryos
(A,C,E,G,I,K,M,O) and
moderate phenotype Hand1-overexpressing embryos
(B,D,F,H,J,L,N,P) at
E9.5. (I-P) Sagittal sections of the control (I,K,M,O) and
Hand1-overexpressing (J,L,N,P) hearts. (Q) Quantitative
real-time PCR analysis on RNA extracted from control or severe phenotype
overexpression embryos for an array of cardiac markers. Means and standard
deviation bars with 95% confidence limits are shown.
*P<0.05, **P<0.01. at, atrium;
co, control; lv, left ventricle; oe, overexpression; oft, outflow tract; rv,
right ventricle. Scale bar: 100 µm in A.
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