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Fig. 6. Functional redundancy between sox9b and sox10 in DRG
neuron development. sox9b morpholino knock-down results in
decreased Hu+ sensory neuron number in 5 dpf wild-type
(A,B) and sox10 mutant (C,D) embryos.
Sox9b morpholino injection into wild type (B) disrupts the regular
DRG pattern of uninjected wild-type siblings (A), resulting in reduced numbers
of DRGs (arrows), fewer DRG neurons and disorganised patterning of DRGs. These
features are also typical of sox10 mutant embryos (C), although the
latter show a more severe phenotype. Injection of sox9b morpholino
into sox10 mutants results in a dramatic reduction in DRG sensory
neurons (D). (A-D) Lateral views of trunk. (E) Quantitation (mean+s.d.)
of total number of trunk Hu+ sensory neurons in 5 dpf wild-type and
sox10 mutant embryos after injection with sox9b morpholinos
as shown (n=10 for all conditions). Asterisk indicates statistically
significant differences from respective controls (P<0.05;
Student's t-test). Scale bar: 50 µm.
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