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Fig. 6. Potential binding sites for mir-84 and paralogs in the
3' UTR of nhr-25. (A) The 3' UTR of
C. elegans nhr-25, corresponding to nucleotides 35690
through 36438 of cosmid F11C1 (Accession number: emb|Z54270). Lines
denote potential binding sites for let-7 and related miRNAs, as
indicated. (B) Vertical lines indicate potential base-pairing between
the 3' UTR of C. elegans nhr-25 and the
let-7-like miRNA, for each site shown in A. The predicted free energy
of folding is indicated. Sequence alignments show conservation of the putative
binding sites in the 3' UTRs of predicted nhr-25 orthologs from
C. briggsae (Accession number: emb|CAAC01000078) and
C. remanei (contig 0.60, nucleotides 49497 through 50100).
Asterisks indicate nucleotides perfectly conserved among all three species,
including seed sequences for the predicted mir-84 and let-7
sites. Colons indicate substitutions within seed sequences of the predicted
mir-48 and mir-241 binding site compatible with G:U
base-pairing.
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