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Fig. 10. rab11 mutants have a morphological phenotype at the NMJ that is suppressed by bchs. (A) Confocal images of muscle 6/7 of abdominal segment 3 labeled with anti-HRP to outline neuronal membrane. Compared with controls and bchs mutants, rab11^ex1/rab11^93Bi animals have an increased density of synaptic boutons and an increased percentage of boutons that are branched (connected to three or more adjacent boutons; arrowheads). Both defects are suppressed in bchs¹⁷/bchs¹²;rab11^ex1/rab11^93Bi double mutants. (B,C) Quantification of bchs-dependent rab11 NMJ defects in bouton density (B) and branching (C). Bouton density (bouton number/µm² muscle area) in rab11^ex1/rab11^93Bi mutants is 225% of control (P<0.0001). This defect is suppressed in bchs¹⁷/bchs¹²;rab11^ex1/rab11^93Bi double mutants (P<0.01 compared to rab11^ex1/rab11^93Bi). In rab11^ex1/rab11^93Bi mutants, the fraction of branching boutons is 266% of control (P<0.0001). This defect is also suppressed in bchs¹⁷/bchs¹²;rab11^ex1/rab11^93Bi double mutants (P<0.0001 compared to rab11^ex1/rab11^93Bi). n=14 for each genotype. Scale bars: 10 µm.

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