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Figure 4


Fig. 4. bchs mutations suppress the lethality of rab11 mutants.Sixty second-instar larvae of each genotype were placed in identical vials and monitored for survival to adulthood. Df is Df(2L)cl7, a chromosome deleted for bchs. Data in A and B represent two independent sets of experiments that were not pooled because the survival of rab11 mutants varied slightly between them. (A) bchs mutations reduce lethality of rab11 hypomorphs (P<0.01 for Df(2L)cl7/bchs17;rab11ex1/rab1193Bi vs rab11ex1/rab1193Bi and P<0.0005 for bchs17/bchs12;rab11ex1/rab1193Bi vs rab11ex1/rab1193Bi) (n≥3 vials/genotype, unpaired t-test). (B) Two-fold reduction in bchs gene dosage reduces lethality of rab11 hypomorphs. Compared to rab11ex1/rab1193Bi: P<0.005 for Df(2L)cl7/+;rab11ex1/rab1193Bi, P<0.0005 for bchs17/+;rab11ex1/rab1193Bi and P<0.01 for bchs17/bchs12;rab11ex1/rab1193Bi (n≥5 vials/genotype). Error bars are s.e.m.





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