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Figure 2


Fig. 2. Generalized chondrodysplasia in Bmpr1aCKO and Bmpr1aCKO;1b+/- neonates. (A,B) Chondrodysplasia in Bmpr1aCKO mice is exacerbated in Bmpr1aCKO;1b+/- mice. (C) Bmpr1aCKO and Bmpr1aCKO;1b+/- mice exhibit multiple axial defects. (D) The dorsal arches (da) of the vertebrae are short and fail to fuse in mutants. (E,F) Forelimb (E) and hindlimb (F) defects. All long bones are shortened in Bmpr1aCKO mice, and the scapula is hypoplastic. These defects are exacerbated in Bmpr1aCKO;1b+/- mice, in which the distal epiphyses of the humerus and femur are greatly reduced. f, femur; fi, fibula; h, humerus; r, radius; s, scapula; t, tibia; u, ulna; eo, exoccipital bone; so, supraoccipital bone; C1, first cervical vertebra.





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