spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 3


Fig. 3. Growth-plate defects in Bmpr1aCKO and Bmpr1aCKO;1b+/- mice. (A,B) Alcian blue-stained sections through E14.5 (A) and E16.5 (B) distal femurs. Restriction in the width of the growth plate at the junction between the resting and proliferative zones is observed in Bmpr1aCKO and Bmpr1aCKO;1b+/- mice compared with wild-type. (C) H/E-stained sections through columnar zones of E16.5 wild-type, Bmpr1aCKO and Bmpr1aCKO;1b+/- littermates reveal a failure to adopt a flattened cell shape and intercalate in mutants. (D) H/E-stained sections through the hypertrophic zones of E16.5 wild-type, Bmpr1aCKO and Bmpr1aCKO;1b+/- littermates reveal the accumulation in mutants of cells with tightly packed nuclei (arrows), a characteristic feature of late hypertrophic chondrocytes. hyp, hypertrophic zone; ph, prehypertrophic zone; prol, proliferative zone; res, resting zone.





Right arrow Return to article