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Figure 5


Fig. 5. Defects in hypertrophic differentiation in Bmpr1aCKO mice. (A) E14.5 and (B) E16.5 distal femoral growth plates immunostained for markers of hypertrophic differentiation. In B, the length of the hypertrophic zone is demarcated by a black bar. The region of marker expression is demarcated by blue double-headed arrows. There is an increase in the overall length of the hypertrophic zone and a disproportionately enlarged zone of late hypertrophic chondrocytes in mutants at E16.5.





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