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Figure 8


Fig. 8. Elevated pSTAT and pERK1/2 in Bmpr1aCKO;1b+/- growth plates. All sections are E16.5 distal femurs. (A) p-STAT1 immunostaining. (B) Quantification of increased p-STAT1 in mutants, expressed as percent positive cells. (C) p-ERK1/2 immunostaining in the hypertrophic (upper) and periarticular (lower) region. P-ERK1/2 immunostaining can be detected in hypertrophic chondrocytes, but there is no detectable difference in the number of positive cells in this region. An increased percentage of p-ERK1/2-staining cells can be observed in the outlined periarticular (resting) zone in mutants. *P<0.01; **P<0.001.





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