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Figure 9


Fig. 9. Expanded domain of FGFR1 expression in Bmpra1CKO and Bmpr1aCKO;1b+/- growth plates. Immunofluorescence staining for FGFR1 in (A) wild-type, (B) Bmpr1aCKO and (C) Bmpr1aCKO;1b+/- distal femurs at E16.5. Intense staining is restricted to the hypertrophic zone (arrow) in wild-type mice. In Bmpr1aCKO mice, intense staining for FGFR1 persists in the expanded hypertrophic zone in (arrow), but is also seen in epiphyseal and columnar chondrocytes. A similar expansion of the domain of FGFR1 expression is observed in Bmpr1aCKO;1b+/- growth plates.





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