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Fig. 2. Stat92E is required for eye development. In panels A-C,F,G clones were generated using ey-flp in a Minute background. (A) +M⁺. (B,C) stat92E^85C9 M⁺. The loss of stat92E results in a small-eye (B) or a no-eye (C) phenotype. These adults also exhibit excess head cuticle (C, arrow). (D) stat92E^85C9 M⁺ adults carrying a UAS-3HA stat92E transgene. The stat92E^85C9 M⁺ small-eye phenotype can be rescued by the ectopic expression of a full-length copy of stat92E. (E) Wild-type adults carrying a UAS-3HA stat92E transgene. Overexpression of this transgene using the ey-GAL4 driver (ey>stat92E) does not alter the size of the adult eye. (F) stat92E³⁹⁷ M⁺. (G) stat92E⁰⁶³⁴⁶ M⁺. Like stat92E^85C9, these stat92E hypomorphic alleles result in a reduction in the size of the adult eye (F,G). (H,H') Adults carrying stat92E^85C9 clones generated using ey-flp in a wild-type (i.e. non-Minute) background. (H) Dorsal view; (H') lateral view. Both ectopic cuticle (arrow) and ambiguous, ectopic structures (arrowheads) are observed in the eye field of adults carrying stat92E^85C9 clones. (I) Dorsal view of a + M⁺ adult that exhibits symmetrically patterned eyes and head cuticle. (J,K) Dorsal views of a stat92E^85C9 M⁺ adult that lacks ommatidia, has an altered pattern of macrochaete and excess head cuticle (arrow) (J) or exhibits only a rudimentary head (K). (L) Adult carrying a UAS-wg transgene in a wild-type background. Overexpression of a wg transgene using the ey-GAL4 driver (ey>wg) results in a no-eye phenotype indistinguishable from the stat92E^85C9 M⁺ no-eye phenotype (C).

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