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Fig. 3. Abnormalities in gene expression in the SMG of
Cp2l1tra/tra mice. (A-D,G) In situ
hybridization analysis of the SMG at birth. Expression of the duct-specific
genes keratin 7 (A), Gk-6 (B), Fxyd2b (C), Scnn1b
(D) and keratin 19 (G) was abnormal in Cp2l1tra/tra mice
compared with Cp2l1+/tra mice. (E) Expression of
CP2L1 and keratin 7 examined in adjacent sections of the nasal gland. In the
duct of the nasal gland, Cp2l1 (lacZ expression; left) was
coexpressed with keratin 7 (right) in control Cp2l1+/tra
mice (upper panels). In Cp2l1tra/tra mice (lower panels),
based on the morphology and the expression of Cp2l1 (left), the duct
was formed, although keratin 7 (right) was not expressed. (F)
Comparison of mRNA expression levels in the newborn SMG of
Cp2l1+/tra and Cp2l1tra/tra mice by
quantitative RT-PCR. *P<0.005. Scale bars: 100
µm.
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