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First published online November 7, 2006

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Insight into JAK/STAT-Wg connections

During development, uniform populations of cells acquire regional differences to form domains that give rise to distinct organs. Drosophila imaginal discs are good systems in which to study the signalling molecules that control this process. On p. 4721, Ekas and co-workers reveal that an unsuspected interaction between JAK/STAT and Wingless (Wg) signalling promotes regional specification in the eye imaginal disc. Wg signalling defines which part of this disc forms head tissue, whereas activation of the Drosophila STAT transcription factor Stat92E by the JAK tyrosine kinase Hopscotch is thought to promote disc growth but not patterning. Now, though, the researchers show that tissue lacking stat92E is transformed from retinal tissue into head cuticle (a phenotype also caused by ectopic wg signalling) and that wg expression is repressed in cells expressing hyperactivated Stat92E. They conclude that repression of wg expression by the JAK/STAT pathway promotes specification in the Drosophila eye imaginal disc and speculate that a similar interaction might control mammalian eye development.

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Related articles in Development:

JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila

Laura A. Ekas, Gyeong-Hun Baeg, Maria Sol Flaherty, Aidee Ayala-Camargo, and Erika A. Bach
Development 2006 133: 4721-4729. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?