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Fig. 1. Models of E10.5 midline germ cell death. (A) Midline
expression of cell death factors (red arrows) and/or the activation of cell
death factor receptors of midline germ cells may activate the extrinsic
apoptotic pathway in PGCs (green). (B) Loss of survival signaling in
the midline at E10.5 due to restricted expression of a survival factor (yellow
arrowheads) or inactivation of a survival factor receptor in midline germ
cells may activate the intrinsic apoptotic pathway.