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Fig. 6. Regulation of ato and integration of the ey/Pax6 and ato pathways. (A) The regulatory elements controlling the early phase of ato expression in the fly eye lie within a 1.2 kb region located 3.1 kb downstream of the ato transcription unit (t.u.). The early-ato stripe and its intermediate clusters result from the integration of multiple regulatory inputs through separate enhancers. A likely model for the regulation of ato by the RD network involves the formation of an Ey-So (or Ey-So-Eya) complex onto adjacent Pax6 and So cis-regulatory sites present within the evolutionarily conserved A1 box. (B) Proposed integration of eye specification and neurogenic inputs during eye development. The RD network directly controls ato transcription in eye progenitor cells and, most likely indirectly, modifies the neurogenetic program downstream of ato. Black arrows indicate regulatory interactions based on genetic and molecular evidence (solid) or genetic evidence only (dashed).

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