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Figure 2


Fig. 2. Defective specification of first branchial arch undifferentiated core mesoderm in Pitx2 mutants. (A-C) Myogenin and (D,E) MyoD fail to be expressed normally in Pitx2 mutant embryos. (F-I). MyoR, a marker of undifferentiated core mesoderm, fails to be expressed in the Pitx2null mutant embryos while another marker of undifferentiated progenitors. (J,K) Pitx2 expression in control and Tbx1null mutant embryos. Arrows denote first branchial arch hybridization signal or absence of signal. Arrowheads in F,G denote signal in the second branchial arch.





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