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Fig. 7. Model of Ldb1 complexes in uninduced MEL cells. The horizontal
arrows indicate that the balance of interaction is towards the large complex
in proliferating noninduced cells. Upon the induction of differentiation and
termination of proliferation the level of Eto-2 drops whereas the level of
Lmo4 rises, hence the equilibrium would shift towards the smaller complexes.
The presence of several DNA binding proteins in a single complex may explain
the role of Ldb1 as a facilitator of long-range interactions.
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