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Fig. 1. Tbx20 is expressed by branchiomotor and visceromotor
neurons. (A-D) In situ hybridization analysis of Tbx20
expression in flat-mounted hindbrains between E10.5 and E13.5. Tbx20
is expressed in ventral columns of motor neurons flanking the midline at E10.5
(A). Trigeminal neurons are labeled at r2 (black arrowhead) and facial neurons
at r4 (white arrowhead). (E-H) Isl1 (red) and Phox2b (green)
co-expression (yellow) defines the location of BM and VM neurons in
flat-mounted hindbrains. The expression of Tbx20 mirrors the pattern
of Isl1 and Phox2b double-labeling. (I-L) Summary depicting the cell
body migration patterns and transcription factor profiles of hindbrain motor
neurons. At present, it is unclear whether all or only a subset of
vestibuloacoustic neurons (blue) cross the midline. (M-P)
Immunohistochemistry of E11.5 hindbrain transverse sections. Facial neurons
co-express Isl1, Tbx20 and Phox2b. Vestibuloacoustic neurons (white arrowhead)
express Gata2 and Isl1. (P) Abducens (VI) SM neurons at r5 lack Tbx20; the
dashed line indicates the border between facial (VII) and abducens (VI)
neurons. Scale bars: in H, 500 µm for A-H; in P, 50 µm for M-P.
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