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Figure 3


Fig. 3. BM/VM cells lacking Tbx20 do not convert their fate into somatic motor neurons. (A,B) The SM neuron marker Hb9 is expressed normally in E11.5 flat-mounted hindbrains from Tbx20 cKOs. (C,D) Isl1 (red) and Phox2b (green) expression in r8 transverse sections from E10.5 Tbx20 mutants and controls. Hypoglossal (XII) SM cells express Isl1 (red) whereas spinal accessory (XI) BM neurons co-express Isl1 and Phox2b (yellow). (E) Quantification of the number of SM neurons (Hb9+ or Isl1+/Phox2b-) in Tbx20 mutants and controls at r5 (E11.5) and r8 (E10.5). Each bar represents the average of at least eight sections collected from three different embryos; mean±s.e.m. Scale bars: in B, 500 µm for A,B; in D, 30 µm for C,D.





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