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Fig. 7. Model of PcG complex assembly at Hox target loci. Nucleosomes and
methylated H3-K27 are depicted as blue ovals and orange diamonds,
respectively. Clustered YY1 binding sites are indicated in red. The purple
line represents potential cooperative interactions between RNA molecules and
PcG proteins. Based on previous PcG and trxG mutant analysis
(Yu et al., 1995;
Yu et al., 1998;
Deschamps et al., 1999;
Tomotsune et al., 2000), the
transition from initiation to maintenance of Hox gene expression should occur
between E9 and E10 of mouse development, herein referred to as `Early
Maintenance' phase. Complex assembly during the `Late Maintenance' phase was
ascertained from E12.5 embryos.
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