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First published online November 21, 2006

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Tbx20: a program for migration

During brain development, neurons migrate stereotypically to establish the correct neuronal circuitry. T-box transcription factors control the development of many migrating cells but do they have a role in the developing CNS? On p. 4945, Samuel Pfaff and coworkers reveal that Tbx20 regulates the cell body migration of several types of mouse cranial motor neurons. The researchers show that migrating branchiomotor/visceromotor (BM/VM) neurons in the hindbrain express Tbx20 during neuronal circuit formation. By generating conditional mutant mice in which Tbx20 was deleted in neurons, the authors show that the migration patterns of BM/VM neurons are disrupted in the absence of Tbx20, while hindbrain patterning and post-mitotic motor neuron generation remain normal. In particular, the authors show that facial motor neuron migration defects are associated with the down-regulation of multiple key components of the planar cell polarity (PCP) pathway. Thus, the authors conclude, Tbx20 regulates facial motor neuron migration by controlling the PCP pathway while regulating the migration of other BM/VM neurons by a different means.

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T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration

Mi-Ryoung Song, Ryuichi Shirasaki, Chen-Leng Cai, Esmeralda C. Ruiz, Sylvia M. Evans, Soo-Kyung Lee, and Samuel L. Pfaff
Development 2006 133: 4945-4955. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?