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First published online January 12, 2006

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Reelin-in neocortical layers

The neocortex – the outer region of the mammalian brain – contains distinct layers of cells that develop in a specific spatiotemporal order. Reelin, which is mainly made by Cajal-Retzius (CR) cells in the developing neocortex, is essential for this process, but it is unclear whether this secreted glycoprotein provides positional information or is permissive for cell migration. On p. 537, Yoshida and colleagues provide strong evidence for the latter role. CR cells arise from the cortical hem of the developing mouse brain. Unexpectedly, when the researchers genetically ablated the hem, neocortical layers formed in the normal order in mutant embryos, even though most CR cells were lost; in reeler mice, which lack functional reelin but have CR cells, the layers are inverted. The researchers suggest that reelin diffusing in from elsewhere in the brain can compensate for CR cell loss and that, therefore, layer order is not driven by positional information from a localised source of reelin.

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Related articles in Development:

Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order

Michio Yoshida, Stavroula Assimacopoulos, Kevin R. Jones, and Elizabeth A. Grove
Development 2006 133: 537-545. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?