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First published online January 12, 2006

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A new conserved role for Wnts in gastrulation?

During gastrulation, morphogenetic movements establish the three embryonic cell layers. In sea urchins, secondary mesenchyme cells (SMC) at the vegetal pole trigger the formation of the archenteron, the central cavity of the gastrula that later develops into the primitive gut. On p. 547, Croce and co-workers report that a newly identified sea urchin Wnt receptor – Frizzled (Fz) 5/8 – is required in SMCs to control archenteron invagination. They show that Fz5/8 is expressed only in the animal domain and in the SMCs during sea urchin embryogenesis. Loss-of-function analyses indicate that Fz5/8 is not involved in the early specification of embryonic cell types but is required to control the primary invagination of the archenteron, which it does through the non-canonical planar cell polarity pathway of Wnt signalling. The researchers suggest that Fz5/8 modulates the morphogenetic movements that initiate gastrulation by controlling SMC adhesion, shape and polarity, a mechanism that is likely to be conserved in vertebrates.

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Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development

Jenifer Croce, Louise Duloquin, Guy Lhomond, David R. McClay, and Christian Gache
Development 2006 133: 547-557. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?