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Fig. 1. Phylogenetic tree of the superfamily of small GTPases. Phylogenies were reconstructed using a neighbor-joining algorithm and p-distance model (p=n_d/L, where n_d=number of amino acids different between two aligned sequences and L=number of sites compared). The bar sets a value of p. Thus, p-distance value in the pairing of XlRas-dva: with another protein, e.g. with GgRas, is 0.65; with XlRab1A or XlRho is 0.69; with XlRan is 0.79; with GgArf1 is 0.85; with GgRbj is 0.78; with GgGem is 0.73; with GgRas-dva is 0.44; and with XtRas-dva is 0.06. Initials before the protein name represent respective organisms, as follows: Hs, Homo sapiens; Mm, Mus musculus; Gg, Gallus gallus; Xl, Xenopus laevis; Xt, Xenopus tropicalis; Dr, Danio rerio. Every colored area indicates an individual family of small GTPases.

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