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Fig. 7. Ras-dva downregulation, in contrast to Ras, can interrupt FGF8a
signaling in the anterior ectoderm. (A) Two crescent-shaped stripes
of the FGF8a expression in the anterior ectoderm of the
Xenopus neurula (left half) are exactly coincident with the anterior
and posterior borders of the Ras-dva expression domain (right half).
(B-D) Ras-dva downregulation, in contrast to Ras, interferes with
FGF-8a signaling in anterior ectoderm in Xenopus embryos.
(B,B') FGF-8a mRNA injection induces ectopic BF-1
expression (red arrow). (C,C') Co-injection of FGF-8a and
DN-Ras-dvaT22N RNAs results in inhibition of BF-1 expression
in the injected area (black arrow). (D,D') Co-injection of
DN-RasS17N with FGF8a did not affect the BF-1
activating signal from FGF8a (red arrow). These results were revealed by
whole-mount in situ hybridization in neurula stage Xenopus embryos.
All embryos are shown from the anterior, dorsal side upwards.
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