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Fig. 6. Partial rescue of the loss of Nurr1+ and Th+ cells
in Ngn2 mutant mice by endogenous or overexpressed Mash1.
(A) At E11.5, Mash1 is transiently downregulated in zone 1 of
Ngn2–/– mice (arrow), but has partially
recovered by E13.5. (B) Substitution of Ngn2 expression by
Mash1 (Ngn2KIMash1/KIMash1, abbreviated to
Ngn2M/M) did not rescue the reduction in number of
Th+ cells observed in Ngn2 mutants at E11.5.
(C,E-G) However, Mash1 overexpression partially rescues the
loss of Th+ DA neurons at E14.5. (D,H-J) The greater loss of
Nurr1+ cells in Ngn2;Mash1 double mutants than in
Ngn2 single mutants indicates that endogenous Mash1 partially rescues
the loss of Nurr1+ precursors at E14.5 (B-D, n=3-6;
***P<0.001, one-way ANOVA, with Bonferroni's correction
for multiple comparisons). Scale bar: 100 µm in A; 20 µm in E-J.
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