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Fig. 3. Correct specification of mesDA neurons in Ngn2 mutants. In wild-type
mice, the two major mesDA neuron subtypes, the SN and VTA neurons, are
characterized by their expression of Girk2 (in SN DA neurons) and calbindin
(in VTA DA neurons). (A-L) In postnatal Ngn2 mutant
mice (D,E), double-stained sections showed that the expression of calbindin
(red, E,F) in the Th-positive VTA neurons (green) was similar to that
seen in wild-type mice (B,C), and Girk2 (red, K,L) was expressed in
Th-positive SN neurons (green) in a pattern indistinguishable from that of
wild type (H,I). (M-R) The expression of Pitx3 (red) was maintained in
all Th-positive neurons (green) in Ngn2 mutants (R). Scale bars: 100
µm.
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