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Fig. 7. The development of non-DA neurons in the VM is unaffected in the Ngn2
mutant. In the heterozygotes, the Isl1-positive oculomotor neurons show
weak GFP-expression at E11.5, and are thus presumably derived from the
Ngn2-expressing VZ progenitors cells. Nevertheless, the number of
Isl1-positive cells was unaffected in the Ngn2 mutants, both at E11.5
(A,D) and at P0 (H,K). Similarly, the Brn3a-positive neurons of
the red nucleus were not affected in the Ngn2 mutant, neither at
E13.5 (G,J), nor at P0 (I,L). (B,E) GFP staining at
E11.5; (C,F) Merged image of A,B and D,E, respectively.
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