|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 2. Cells derived from the hem fit the criteria of Cajal-Retzius cells.
(A-C) From E10.5-12.5, hem-derived ß-gal-labeled cells (arrows)
migrate into the MZ. (D,E) E18.5 cortical hemispheres in rostral (D)
and lateral (E) views. ß-Gal-expressing cells cover the neocortex with
rough boundaries at the olfactory bulbs and future rhinal sulcus (arrows).
Caudally, some cells migrate below the latter boundary (asterisk).
(F,G) p73 immunofluorescence in cells of the hem, the cpx and the MZ of
the hippocampal (F) and neocortical primordia (G). Asterisks in F,G indicate
regions also shown at higher magnification (insets). Many cells are
double-labeled with ß-gal, indicating their origin in the hem (arrows,
and higher magnification insets). A few were positive only for p73 (for
example, see arrowhead in G). (H,I) Hem-derived, ß-gal+ cells in
the neocortex (H) and hippocampus (I) were reelin-immunoreactive (arrows),
although some reelin-positive cells were single-labeled (arrowhead in I).
(J,K) Hem-derived cells were not immunoreactive for GABA. cpx, choroid
plexus; ncx, neocortex; ob, olfactory bulb; reln, reelin.
|
