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Fig. 3. Constructing a Wnt3a-IRES-xneox-dt-a mouse line to ablate the
hem. (A, top to bottom) Wild-type Wnt3a allele;
Wnt3a-IRES-xneox-dt-a allele; activation of dt-a toxin by
Cre-recombination, using an Emx1-IRES-Cre mouse line
(Gorski et al., 2002).
(B) Recombination in the telencephalon was confined to the hem, which
was almost completely ablated by E10 in
Wnt3aIRESxneoxdt-a/+;Emx1IRESCre/+ mice (dorsal views).
Wnt3a expression marks the hem at E12.5 (medial view) but not in a
hem-ablated brain (arrow indicates caudal hem remnant). Expression of
Lmx1a marks the hem and cpx; a part of the cpx (arrow) remains in the
hem-ablated mouse.
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