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Fig. 5. Other sources provide only transient or sparse Reln+ cells to
the hem-ablated neocortex. (A-E) E13.5 cerebral hemispheres from
control (E) or hem-ablated (A-D) mice, processed with in situ hybridization to
show Reln or p73 expression. (A,D,E) Lateral views of
hemispheres, rostral to the left; (B,C) dorsal views, rostral is downwards.
(A-E) In hem-ablated cortex, ventral (A) and rostral (B) sources appear to
provide Reln+ cells (arrows in A,B) to the neocortex. Dorsal cells
that may originate from the rostral source do not express p73 (arrow
in C), and thus do not fit current criteria for CR cells. In a control (E),
Reln+ CR cells cover lateral neocortex; in a hem-ablated mouse, the
ventral source provides few Reln+ cells (arrows in D). (F-K)
Coronal sections through E12.5, E13.5 and E15.5 hemispheres, medial towards
the right, processed to show Reln expression (arrows). Evidence for a
rostromedial source of Reln+ neurons (arrows) in sections at E12.5 in
both control (F) and hem-ablated brains (I). In the latter, a small domain of
Reln+ cells remains in medial cortex at E13.5 (arrow, J), but not at
E15.5 (K).
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