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Fig. 6. Diffuse expression of Reln in control and hem-ablated mice.
(A-C) Sagittal sections through E15.5 brains; (D-F) coronal
sections through E18.5 neocortex. At E15.5 and E18.5 in control mice (A,D),
but not hem-ablated mice (B,E), a dense layer of Reln+ CR cells fills
the MZ (asterisk in B indicates the region of hem loss and consequent failure
of hippocampal development). Below this is more diffuse Reln
expression. At E15.5, a band of low Reln+ expression appears in the
IZ/SVZ in both mutants and controls (A-C). By E18.5, scattered Reln+
cells appear in layers IV/V (D-F). (F) Layers defined by expression of
Rorb: Reln+ cells are yellow, Rorb expression is
light purple. Arrows in each panel indicate Reln+ cells.
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