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Fig. 7. In the absence of CR cells the preplate splits and neocortical layers
are ordered correctly. (A-F) Coronal sections through control or
hem-ablated neocortex. At E13.5, calretinin and CSPG-immunoreactivity (IR)
distinguished the preplate (A,C). By E15.5, in control mice, two bands
of calretinin- and CSPG-IR marked the MZ and subplate (B,D). Only the
lower, subplate band appeared in hem-ablated animals; the upper band, which
labeled CR cells in controls, was not detected (B,D). (E,F) In control
neocortex at E18.5, expression patterns of SCIP (Pou3f1)
SorLA (Sorl1), Rorb, ER81 (Etv1),
Fezl and Tbr1 distinguished layers II/III, IV, V, VI and the
subplate, along the pial-to-ventricular axis (E). In hem-ablated mice,
expression of each gene appeared in a highly similar pial to ventricular order
(F). Expression of some genes, notably SorLA, showed abnormal
diffusion, indicating modest migration defects.
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