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First published online January 25, 2006

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Hox gets surprisingly direct

Almost all animal species use Hox genes to determine developmental cell fate and morphology, and on p. 641, Cameron and co-workers investigate how Hox genes regulate programmed cell death. The C. elegans Hox gene mab-5 is required for the programmed death of two related cells in the posterior ventral nerve cord: P11.aaap and P12.aaap. Programmed cell death in C. elegans requires the BH3-domain gene egl-1, and the researchers found that, in the P11.aaap cell, MAB-5 (together with its cofactor CEH-20) activates egl-1 transcription by directly interacting with a consensus binding site in the egl-1 regulatory sequence (although, remarkably, the death of P12.aaap is determined in a different fashion). This is the first time that a cell biological effector gene - rather than a transcription factor - has been found to be directly regulated by Hox proteins in C. elegans. Together with similar findings from Drosophila, this indicates that non-homeotic targets of Hox proteins, including targets that control programmed cell death, might be more common than previously thought.

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Related articles in Development:

Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1

Huarui Liu, Tamara J. Strauss, Malia B. Potts, and Scott Cameron
Development 2006 133: 641-650. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?