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First published online January 25, 2006

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Charleston partners needed for shaping cells

The first morphogenetic process of Drosophila development is the formation of the primary epithelium by cellularisation, during which invagination of the plasma membrane packages the nuclei into around 6000 distinct cells. Using microarrays, RNAi and time-lapse phenotyping, Lecuit and colleagues have identified several novel genes that profoundly affect cellular architecture during cellularisation. Their paper on p. 711 focuses on one of these genes - charleston (char). They show that epithelial nuclei lacking Char (owing to mutation or RNAi) fail to elongate during cellularisation and instead remain spherical, which distorts cell shape and the normal columnar morphology of the epithelium. Unexpectedly, the binding of microtubules to the nuclear envelope is unaffected in char RNAi embryos. Instead, Char's localisation to the inner nuclear membrane indicates that it directly controls the structural organisation of the nuclear envelope. The authors suggest that Char is a component of a nucleoskeleton needed by the nuclear membrane to respond to microtubules; whether this is true will become clear as its molecular partners are identified.

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Related articles in Development:

Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation

Fanny Pilot, Jean-Marc Philippe, Céline Lemmers, Jean-Paul Chauvin, and Thomas Lecuit
Development 2006 133: 711-723. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?